引用本文:刘尊亮,梁思敏,唐显力,刘朝东.Ⅲ型前列腺炎患者前列腺液中血管活性肠肽和肿瘤坏死因子-α的表达及意义[J].重庆医科大学学报,2014,38(6):793~796
Ⅲ型前列腺炎患者前列腺液中血管活性肠肽和肿瘤坏死因子-α的表达及意义
Expression and significance of vasoactive intestinal peptide and tumor necrosis factor-α in prostatic secretion of patients with type Ⅲ prostatitis
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中文关键词:  Ⅲ型前列腺炎  血管活性肠肽  肿瘤坏死因子-α
英文关键词:type Ⅲ prostatitis  vasoactive intestinal peptide  tumour necrosis factor-alpha
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刘尊亮,梁思敏,唐显力,刘朝东 重庆医科大学附属第一医院泌尿外科重庆 400016 
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中文摘要:
      目的:观察Ⅲ型前列腺炎患者前列腺按摩液(expressed prostatic secretion,EPS)中血管活性肠肽(vasoactive intestinal peptide,VIP)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的表达,探讨VIP和TNF-α对Ⅲ型前列腺炎临床诊断及疗效判定价值。方法:Ⅲ型前列腺炎患者69例,其中:Ⅲa型37例、Ⅲb型32例,采用ELISA法检测EPS中VIP和TNF-α的含量。结果:Ⅲa、Ⅲb组VIP含量[Ⅲa组(51.33±10.63) pg/ml,Ⅲb组(47.45±7.55) pg/ml]均明显高于正常对照组[(25.95±4.74) pg/ml];Ⅲa组TNF-α含量[(76.08±15.44) pg/ml]明显高于Ⅲb组[(27.85±6.43) pg/ml]及正常对照组[(10.30±3.62) pg/ml],Ⅲb组[(27.85±6.43) pg/ml]明显高于正常对照组[(10.30±3.62) pg/ml],差异均有统计学意义(P=0.000)。Ⅲ型前列腺炎患者VIP含量变化与慢性前列腺炎症状指数评分呈正相关(r=0.711,P=0.000);与国际前列腺症状评分呈正相关(r=0.428,P=0.000)。结论:VIP、TNF-α在Ⅲ型前列腺炎患者EPS中的表达较正常青年男性显著增高,TNF-α在Ⅲa组及Ⅲb组间存在统计学差异。VIP及TNF-α的检测可能为Ⅲ型前列腺炎的临床诊断和治疗评估提供有价值的参考指标。
英文摘要:
      Objective:To explore the expression of vasoactive intestinal peptide(VIP) and tumor necrosis factor-α(TNF-α) in ex-pressed prostatic secretions(EPS) of patients with type Ⅲ prostatitis and to discuss the value of VIP and TNF-α in the diagnosis and treatment of type Ⅲ prostatitis. Methods:Sixty-nine patients with type Ⅲ prostatitis were investigated including 37 cases of type Ⅲa and 32 cases of type Ⅲb. Levels of VIP and TNF-α were measured by ELISA. Results:Contents of VIP in EPS were significantly higher in type Ⅲa and type Ⅲb groups(Ⅲa group:(51.33±10.63) pg/ml;Ⅲb group:(47.45±7.55) pg/ml) than in control group((25.95±4.74) pg/ml). Contents of TNF-α were significantly higher in type Ⅲa group((76.08±15.44) pg/ml) than in type Ⅲb group((27.85±6.43) pg/ml) and control group((10.30±3.62) pg/ml);significantly higher in Ⅲb group than in control group with statis-tical differences(P=0.000). Contents of VIP were positively related with NIH-chronic prostatitis symptom index(r=0.711,P=0.000) and international prostate symptom score(r=0.428,P=0.000). Conclusions:Contents of VIP and TNF-α are significantly higher in type Ⅲ prostatitis groups than in control group. Differences are existed in TNF-α contents between type Ⅲa group and type Ⅲb. Detection of VIP and TNF-α may provide valuable indicators in the diagnosis and treatment of type Ⅲ prostatitis.
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